https://virgool.io/feed/@m_44565644 fa 2026-06-10 12:31:46 https://files.virgool.io/upload/users/3822222/avatar/munbLk.jpg?height=120&width=120 https://virgool.io/@m_44565644 https://virgool.io/@m_44565644/%D8%AA%D8%A7%D8%AB%DB%8C%D8%B1-%D9%85%DB%8C%DA%A9%D8%B1%D9%88%D8%A8%DB%8C%D9%88%D9%85-%D8%B1%D9%88%D8%AF%D9%87-%D8%A8%D8%B1-%D8%A7%D9%88%D8%AA%DB%8C%D8%B3%D9%85-t4mvscoktxsp Introduction: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder withunique characteristics in information processing and social interactions. Recentresearch indicates that the gut-brain axis, particularly through the vagus nerve, playsa role in the pathophysiology of autism. Factors such as gut microbiome composition,mode of delivery (birth method), antibiotic use, and diet can influence this connection.This analytical review examines the current evidence regarding this relationship.Methods: The research methodology of this study is based on a structured reviewconducted through a systematic search of PubMed, Scopus, and Web of Science databases.Key search terms included "Autism Spectrum Disorder," "Gut-Brain Axis," "Gut Microbiota,Studies published between 2010 and 2024 were collected and screened based on inclusioncriteria encompassing human and animal studies, availability of full-text articles, andpublication in peer-reviewed journals.Result: Research indicates that dysfunction of the gut-brain axis, particularly throughthe vagus nerve pathway, plays a determinant role in the pathophysiology of ASD.Studies confirm a significant reduction in microbial diversity and ecological imbalancein the gut microbiota of ASD patients. Specifically, butyrate-producing bacteria showup to 50% reduction while pro-inflammatory bacteria demonstrate up to 3-foldincrease. These alterations are accompanied by impaired vagus nerve signaling,which plays a crucial role in bidirectional gut-brain communication .The consequencesinclude reduced production of essential metabolites, increased blood-brain barrierpermeability, and activation of systemic inflammatory responses. Risk factors such ascesarean delivery (23% increased odds ratio) and childhood antibiotic exposure (34%increased relative risk) exacerbate this dysbiosis .The findings suggest that targetedinterventions modulating microbiota and improving vagus nerve function could provideeffective therapeutic approaches for managing ASD .gut-brain communication. Theconsequences include reduced production of essential metabolites, increased blood￾brain barrier permeability, and activation of systemic inflammatory responses. Riskfactors such as cesarean delivery (23% increased odds ratio) and childhood antibioticexposure (34% increased relative risk) exacerbate this dysbiosis. The findings suggestthat targeted interventions modulating microbiota and improving vagu nerve functioncould provide effective therapeutic approaches fofor managing ASD. Sama Sama Fri, 23 Jan 2026 02:46:38 +0330